Can the data in the HyperDuo Safe mode be rebuilt?
No.
If the hard drive (HDD) becomes defective, all data will be lost. If any or all the SSD(s) becomes defective but the hard drive is still functional, the data inside the HDD can be read and write with the other enclosure without problem.
Under this situation, please turn off the RAID Unit, replace the defective SSD with the new one, turn on the Unit. Then create the HyperDuo Safe mode (or other RAID mode) in the Configuration menu. Move the backup data originally inside the HDD from the other place back to the Unit under the HyperDuo Safe mode.